diff --git a/workflow/qhtcp-workflow b/workflow/qhtcp-workflow
index c702e946..164c0bec 100755
--- a/workflow/qhtcp-workflow
+++ b/workflow/qhtcp-workflow
@@ -574,6 +574,9 @@ install_dependencies() {
   # Install R packages
   echo "Installing R packages"
 
+  # Make R library directory if it doesn't exist
+  [[ -d "$R_LIBS_USER" ]] || mkdir -p "$R_LIBS_USER"
+
   depends_r_str=""
   depends_r_to_string() {
     for d in "${depends_r[@]}"; do